Характерные особенности спектров HLA-аллелей классов I и II у пациентов с различными клиническими формами ювенильного идиопатического артрита в Республике Беларусь

The genes of the major histocompatibility complex (HLA) play a significant role in the genetic predisposition to juvenile idiopathic arthritis (JIA) and determine up to 18 % of disease risk. This work was aimed to reveal associations of the HLA characteristic pattern with two clinically different forms of JIA in the Belarusian population. 24 patients diagnosed with systemic JIA, 24 patients with oligoarticular JIA and 24 healthy controls were included into the study. High-throughput HLA typing for 11 loci was performed using TruSight HLA v2 Sequencing Panel (Illumina) on the MiSeq system. DQB1*04:02:01 (p = 0.026; OR 5.88 [1.20–28.72]), DRB1*08:01:01 (p = 0.07; OR 3.94 [1.01–15.39]) and DR8-haplotype (p = 0.006; OR 3.95 [1.34–11.63]) frequencies were significantly higher in patients with oligoarthritis but not systemic JIA when compared with controls. While DQA1*05:01:01 and DQB1*02:01:01 alleles showed a protective effect against both systemic (p = 0.007, OR 0.08 [0.009–0.65]; p = 0.01, OR 0.09 [0.01–0.83]) and oliarticular JIA (p = 0.026, OR 0.16 [0.03–0.79]; p = 0.046, OR 0.2 [0.04–1.00], the negative association of the DRB1*03:01 allele was revealed only for systemic JIA (p = 0.03, OR 0.11 [0.01–0.88]). Thus, the obtained results suggest that different HLA-patterns are involved into the formation of various JIA subtypes.Гены главного комплекса гистосовместимости HLA играют существенную роль в генетической предрасположенности к ювенильному идиопатическому артриту (ЮИА) и определяют до 18 % риска развития заболевания. Учитывая гипервариабельность генов HLA и специфичность их аллельных спектров в зависимости от популяции, представляло интерес провести HLA-типирование пациентов с ЮИА, проживающих на территории Республики Беларусь, для установления аллелей, ассоциированных с отдельными клиническими формами заболевания. В работе с помощью высопроизводительного секвенирования нового поколения (Illumina) для 48 детей с системным и олигоартикулярным подтипами ЮИА и контрольной группы (n = 24) был определен спектр HLA-аллелей по 11 локусам (HLA-A, B, C, DPA1, DPB1, DQA1, DQB1, DRB1/3/4/5). Установлено, что аллели HLA-DQB1*04:02:01 (OR 5,88 [1,20–28,72], p = 0,026), HLA-DRB1*08:01:01 (OR 3,94 [1,01–15,39], p = 0,07) и гаплотип DR8 (OR 3,95 [1,34–11,63], p = 0,006) ассоциированы с риском возникновения олигоартикулярного ЮИА. Выявлены аллели, снижающие риск развития системной формы заболевания (HLA-DRB1*03:01, OR 0,11 [0,01–0,88], p = 0,03), либо оказывающие протективный эффект по отношению к обеим рассматриваемым формам ЮИА (DQA1*05:01:01 (OR 0,08 [0,009–0,65], p = 0,007 и OR 0,16 [0,03–0,79], p = 0,026) и DQB1*02:01:01 OR 0,09 [0,01–0,83], p = 0,01 и OR 0,20 [0,04–1,00], p = 0,046 для системного и олигоартикулярного ЮИА соответственно). Таким образом, полученные результаты позволяют предположить, что в формировании различных клинических форм ЮИА задействованы различные HLA-паттерны

Результаты современных радиационно-гигиенических обследований приграничных с Республикой Беларусь населенных пунктов Брянской области Российской Федерации. Часть 1: Характеристика населенных пунктов

This study presents results of radiation-hygienic surveys of the Bryansk Oblast settlements bordering the Republic of Belarus. The data were obtained in the course of implementation of measures of the “Program of joint activities of Russia and Belarus within the framework of the Union State for the protection of the population and rehabilitation of the territories affected by the Chernobyl NPP accident” in 2019–2022. The first part of the study presents a general characteristic of the current state of the problem of returning the residents of radioactively contaminated territories to normal living conditions and provides information on the settlements of the surveyed region. The modern demographic composition of the population is considered; the structure of private subsidiary plots is investigated. The results described in this part of the study indicate the main ways, which are relevant for the formation of the internal exposure dose of the public at the current stage of the radiation accident.В статье приводятся результаты радиационно-гигиенических обследований приграничных с Республикой Беларусь населенных пунктов Брянской области, полученные в 2019–2022 гг. в ходе реализации мероприятий «Программы совместной деятельности России и Беларуси в рамках Союзного государства по защите населения и реабилитации территорий, пострадавших в результате катастрофы на Чернобыльской АЭС». В первой части статьи дана общая характеристика современного состояния проблемы возвращения жителей радиоактивно загрязненных территорий к условиям нормальной жизнедеятельности и приводятся сведения о населенных пунктах обследованного региона. Рассмотрен современный демографический состав населения, исследована структура личных подсобных хозяйств. На основании результатов, описанных в данной части публикации, выделены основные пути формирования дозы внутреннего облучения населения, актуальные для современного этапа радиационной аварии

Community outreach projects as a sustainable way of introducing information technology in developing countries

Contains fulltext : 141396.pdf (publisher's version ) (Open Access

COMPOSITION OF LYMPHOCYTE SUBSETS IN THE PATIENTS WITH SEVERE FORMS OF HERPETIC INFECTION

Evaluation of lymphocyte subsets in severe forms of herpetic infection is a necessary diagnostic test. However, interpretation of appropriate data is difficult, due to slight or multidirectional changes of immunological parameters in the patients. In present study, the indices of immune status were assessed in the patients with severe recurrent forms of chronic herpetic infection, being in remission period by the time of study. A detailed personalized analysis of immunological testing data is presented, with respect to the disease duration, recurrence frequency, and other clinical features of severe herpes infection. Various types of correlations between the lymphocyte subpopulations are described for the patients with severe recurrent herpetic infection

Development of Methods Acquiring Real Time Very High Resolution Agricultural Spatial Information Using Unmanned Aerial Vehicle

There is a need for high resolution spatial information to provide quality agricultural spatial information for better monitoring and management of farm activities to increase production and sustainable agricultural economic development. The Unmanned Aerial Vehicles are able to capture very high resolution spatial data that can be transformed into useful geospatial information, databases and digital maps. However, Unmanned Aerial Vehicle methods of acquiring spatial data are yet to be developed. The objective of this study was to develop methods of acquiring real time high resolution agricultural spatial data using Unmanned Aerial Vehicle. A qualitative case study research approach, and data collection method were used to achieve the objective. A ground truth data was carried out to eliminate errors. Unmanned Aerial Vehicle data acquisition system and data processing methods were developed. These methods could be used for better farm management and reduce the cost of inputs like fertilizers

Information Science curriculum design based on community outreach projects

Item does not contain fulltextCSERC'12 : Second Computer Science Education Research Conference, Wroclaw, Polan

Functional-morphological changes in non-alcoholic fatty liver disease after bariatric operations

The objective of the study was to evaluate the effect of bariatric operations on the course of nonalcoholic fatty liver disease (NAFLD) and determine the possibility of using non-invasive diagnostic methods for NAFLD.Material and methods. The published data review of the NAFLD dynamics after bariatric surgery.Results. Currently there is no common opinion on the effectiveness and safety of bariatric operations in NAFLD treatment.Conclusion. Further research and randomized controlled clinical study are needed